What is a Pharmacometric Shiny Application?
A Pharmacometric Shiny Application is an interactive web-based tool developed using Shiny, a framework for creating web applications using the R programming language. This application serves as a user-friendly interface for pharmacokinetic and pharmacodynamic analysis, allowing researchers, clinicians, and pharmacologists—to input data and parameters and receive real-time outputs. The goal is to simplify complex PK or PD computations and provide insightful, actionable information to guide drug development or inform clinical trial design.
Features
Data Upload and Preprocessing
Data Upload: Upload datasets in various formats (CSV, Excel, etc.)
Data Review: View the uploaded data before analysis
Data Cleaning: Options to handle missing data, outliers, etc.
Parameter Input
Compartment Models: Choose from one-compartment, two-compartment, or multi-compartment PK models or PK/PD models
Initial Estimates: Input initial estimates for PK/PD parameters (Vd, Cl, Ka, etc.)
Covariates: Option to include covariates like age, weight, gender, etc.
PK and PD Analysis
PK/PD correlations: Find correlations between PK and PD biomarkers.
Covariates: Explore covariates that affect your PK or PD
Simulations and Predictions
Monte Carlo Simulations: Evaluate different dosing regimens and predict outcomes
Sensitivity Analysis: Understand the effect of varying parameters on PK profiles
Reporting and Visualization
Interactive Plots: Generate interactive concentration-time curves, residual plots, etc.
Downloadable Reports: Summary reports in PDF or Word format, including all tables, plots, and interpretations
Benefits
Accessibility: Easy to access through web browsers, no installation required
Customization: Tailor analyses based on the specific research question
Real-time Results: Receive instant computations and visualizations
User-friendly: Designed for users with minimal programming or statistical knowledge
Collaboration: Easy to share results with team members or external stakeholders
Use Cases
Drug Development: Optimize PK profiles for new chemical entities
Clinical Trials: Pre-study simulations for sample size determination
Therapeutic Drug Monitoring: Individualized dose recommendations
Regulatory Submission: Supporting evidence for regulatory filings
Requirements
Modern web browser (Chrome, Firefox, Safari, etc.)
Internet connection for server-hosted applications
Preprocessed pharmacokinetic data for analysis
Demo
For a live demo or to have us design an application, please contact us.
By offering a combination of ease-of-use, customization, and real-time results, the PK or PD Shiny Applications aims to be an invaluable resource in research and clinical applications.