Pharmacometrics Hot Topics

What is Population Pharmacokinetic Modeling & Simulation?

Population Pharmacokinetics

Population Pharmacokinetics-Pharmacodynamics

Modeling & Simulation

A population pharmacokinetic (also applicable to pharmacokinetic - pharmacodynamic relationships) analysis is a nonlinear mixed-effects modeling approach used to estimate…

What is the Difference Between Bioanalytical and Pharmacokinetic Analyses?

Bioanalytical Analysis

Pharmacokinetic Analysis

The terms ‘bioanalytical analysis’ and ‘pharmacokinetic analysis’ are commonly used interchangeably, despite slight differences in meaning.

What is Pharmacokinetics - Pharmacodynamics (PK-PD)?

Pharmacokinetics

Pharmacodynamics

Pharmacokinetics is the study of what the body does to the drug - it is the movement of a drug into, within and out of the body. It describes the relationship between the…

What is Pharmacometrics?

Pharmacometrics

Pharmacometrics is a quantitative approach to the analysis and interpretation of pre-clinical and clinical trial data. This discipline uses mathematical and statistical…

Harnessing the Power of Exposure-Response Analysis: Revolutionizing Drug Development

Exposure-Response Analysis

Logistic Regression

In the realm of drug development, the pursuit of safe and effective medications is an unwavering goal. To achieve this, exposure-response analysis stands as a vital tool…

What is a Non-Compartmental Analysis (NCA)?

Pharmacokinetics

Non-Compartmental Analysis

Non-compartmental analysis, also known by its acronym NCA, is a simple and descriptive methodology used to understand the pharmacokinetic properties of a drug. It is an a…

What is Clinical Trial Simulation?

Clinical Trial Simulation

Clinical trial simulation is an in silico methodology used to predict the outcomes of different clinical trial designs. It can provide insight into questions that otherwise…

What is Disease Progression Modeling?

Disease Progression Modeling

Disease progression modeling involves the use of mathematical and statistical functions to quantitatively describe how a disease develops and progresses over time. The…